Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice.

ABSTRACT:

Objective

Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation and white adipose tissue (WAT) browning.

Methods

MaR1 actions were tested in cultured murine brown adipocytes and in human mesenchymal stem cells (hMSC)-derived adipocytes. In vivo effects of MaR1 were tested in diet-induced obese (DIO) mice and lean WT and Il6 knockout (Il6^-/-) mice.

Results

In cultured differentiated murine brown adipocytes, MaR1 reduces the expression of inflammatory genes, while stimulates glucose uptake, fatty acid utilization and oxygen consumption rate, along with the upregulation of mitochondrial mass and genes in

SUBMITTER: Laiglesia LM 

PROVIDER: S-EPMC10331312 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature