Longitudinal trajectories in negative symptoms and changes in brain cortical thickness: 10-year follow-up study.

ABSTRACT:

Background

Understanding the evolution of negative symptoms in first-episode psychosis (FEP) requires long-term longitudinal study designs that capture the progression of this condition and the associated brain changes.

Aims

To explore the factors underlying negative symptoms and their association with long-term abnormal brain trajectories.

Method

We followed up 357 people with FEP over a 10-year period. Factor analyses were conducted to explore negative symptom dimensionality. Latent growth mixture modelling (LGMM) was used to identify the latent classes. Analysis of variance (ANOVA) was conducted to investigate developmental trajectories of cortical thickness. Finally, the resulting ANOVA maps were correlated with a wide set of regional molecular profiles derived fr

SUBMITTER: Canal-Rivero M 

PROVIDER: S-EPMC10331319 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature