Zinc for infection prevention in children with sickle cell anemia: a randomized double-blind placebo-controlled trial.

ABSTRACT: Data from small clinical trials in the United States and India suggest zinc supplementation reduces infection in adolescents and adults with sickle cell anemia (SCA), but no studies of zinc supplementation for infection prevention have been conducted in children with SCA living in Africa. We conducted a randomized double-blind placebo-controlled trial to assess zinc supplementation for prevention of severe or invasive infections in Ugandan children 1.00-4.99 years with SCA. Of 252 enrolled participants, 124 were assigned zinc (10 mg) and 126 assigned placebo once daily for 12 months. The primary outcome was incidence of protocol-defined severe or invasive infections. Infection incidence did not differ between treatment arms (282 vs. 270 severe or invasive infections per 100 person-years, r

SUBMITTER: Namazzi R 

PROVIDER: S-EPMC10331409 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature