Iron-enriched Aspergillus oryzae as an alternative to iron sulphate to limit iron accumulation, growth and motility of the enteric pathogen S. Typhimurium.

ABSTRACT: Excess unabsorbed iron in the gastrointestinal tract may select for enteric pathogens and increase the incidence and severity of infectious disease. Aspergillus oryzae (Ao) is a filamentous fungus that has the ability to accumulate and store large amounts of iron, and when used as a supplement or fortificant, has similar absorption to ferrous sulphate (FeSO₄) in humans. The objective of this study was to determine the effect of iron-enriched Ao (Ao iron) compared with FeSO₄ on iron accumulation, growth and motility of the Gram-negative enteric pathogen, S. Typhimurium. S. Typhimurium was cultured in media containing no added iron or 1 μM elemental iron as either Ao iron or FeSO₄. S. Typhimurium culture

SUBMITTER: Miller KM 

PROVIDER: S-EPMC10331431 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature