A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.

ABSTRACT: IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens, including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens activate IgE-bound perivascular mast cells (MCs) throughout the body, causing an extensive systemic release of MC mediators. Through precipitating vasodilatation and vascular leakage, these mediators are believed to trigger a sharp drop in blood pressure in humans and in core body temperature in animals. We report that the IgE/MC-mediated drop in body temperature in mice associated with anaphylaxis also requires the body's thermoregulatory neural circuit. This circuit is activated when granule-borne chymase from MCs is deposited on proximal TRPV1⁺ sensory neurons and stimulates them via protease-activated re

SUBMITTER: Bao C 

PROVIDER: S-EPMC10331449 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature