The association between cholecystectomy and the risk of colorectal cancer: an updated systematic review and meta-analysis of cohort studies.

ABSTRACT:

Background

The effect of cholecystectomy on the development of colorectal cancer (CRC) has prompted a large number of population-based studies. However, the results of these studies are debatable and inconclusive. Our aim in the present study was to conduct an updated systematic review and meta-analysis to explore the causality between cholecystectomy and CRC.

Methods

Cohort studies published in the PubMed, Web of Science, Embase, Medline, and Cochrane databases up to May 2022 were retrieved. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were analyzed using a random effects model.

Results

Eighteen studies, involving 1,469,880 cholecystectomy and 2,356,238 non-cholecystectomy cases, were eligible for the final analysis. Cholecystectomy was not associat

SUBMITTER: Mu L 

PROVIDER: S-EPMC10331452 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature