Establishment and validation of a prognostic nomogram for patients with renal cell carcinoma based on SEER and TCGA database.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a lethal urological malignancy. Precise risk-stratification is very important for decision-making in postoperative patient management. This study aimed to establish and validate a prognostic nomogram of overall survival (OS) in patients with RCC based on Surveillance, Epidemiology, and End Results (SEER) and TCGA database.

Methods

The retrospective data of 40,154 patients diagnosed with RCC during 2010 to 2015 from SEER database (development cohort) and 1,188 patients from TCGA database (validation cohort) were downloaded for analysis. Independent prognostic factors were identified by univariate and multivariate Cox regression analyses and adopted to set up a predictive nomogram of OS. The discrimination and calibration of the nomogra

SUBMITTER: Wang C 

PROVIDER: S-EPMC10331455 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature