High infiltration of CD209⁺ dendritic cells and CD163⁺ macrophages in the peritumor area of prostate cancer is predictive of late adverse outcomes.

ABSTRACT:

Introduction

Prostate cancer (PCa) shows considerable variation in clinical outcomes between individuals with similar diseases. The initial host-tumor interaction as assessed by detailed analysis of tumor infiltrating immune cells within the primary tumor may dictate tumor evolution and late clinical outcomes. In this study, we assessed the association between clinical outcomes and dendritic cell (DC) or macrophage (MΦ) tumor infiltration as well as with expression of genes related to their functions.

Methods

Infiltration and localization of immature DC, mature DC, total MΦ and M2-type MΦ was analyzed by immunohistochemistry in 99 radical prostatectomy specimens from patients with 15.5 years median clinical follow-up using antibodies against CD209, CD83, CD68 and CD163, resp

SUBMITTER: Molina OE 

PROVIDER: S-EPMC10331466 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature