Omnibus test for restricted mean survival time based on influence function.

ABSTRACT: The restricted mean survival time (RMST), which evaluates the expected survival time up to a pre-specified time point τ, has been widely used to summarize the survival distribution due to its robustness and straightforward interpretation. In comparative studies with time-to-event data, the RMST-based test has been utilized as an alternative to the classic log-rank test because the power of the log-rank test deteriorates when the proportional hazards assumption is violated. To overcome the challenge of selecting an appropriate time point τ, we develop an RMST-based omnibus Wald test to detect the survival difference between two groups throughout the study follow-up period. Treating a vector of RMSTs at multiple quantile-based time points as a statistical functional, we construct a Wald χ2 t

SUBMITTER: Gu J 

PROVIDER: S-EPMC10331519 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature