NABP2 as an oncogenic biomarker promotes hepatocellular carcinoma progression and metastasis.

ABSTRACT:

Objectives

To evaluate the role and biological function of nucleic acid binding protein 2 (NABP2) in hepatocellular carcinoma (HCC).

Methods

Our study was based on comprehensive bioinformatics methods and functional analysis experiments using HCC cells to reveal the expression of NABP2, the prognostic role of NABP2, the relationship between NABP2 and the infiltration of immune cells and the expression of immune-related cytokines, potential effective drugs against HCC, and the biological function of NABP2 in HCC.

Results

Our results indicated that NABP2 expression was markedly elevated in HCC, which suggested a worse prognosis and shorter survival time in HCC patients. Moreover, NABP2 was an independent prognostic factor and was associated with cancer-related signal pa

SUBMITTER: Peng H 

PROVIDER: S-EPMC10331651 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature