Comprehensive pan-cancer analysis identifies FHL2 associated with poor prognosis in lung adenocarcinoma.

ABSTRACT:

Background

The FHL family (four-and-a-half-LIM-only protein family) contains five multifunctional proteins (FHL1-5) that are involved in cell survival, transcriptional regulation, and signal transduction. Among these proteins, FHL2 is one of the most reported members in tumors, which is differentially expressed in numerous tumors. However, no systematic pan-cancer analysis of FHL2 has been performed so far.

Methods

We obtained The Cancer Genome Atlas (TCGA) expression profiles and clinical data from Xena database and the Tumor Immune Estimation Resource (TIMER) database. Gene expression, prognosis, mRNA modification, and immune infiltration of FHL2 in pan-cancer were analyzed. Functional analysis validated the potential mechanism of FHL2 in lung adenocarcinoma (LUAD).

Res

SUBMITTER: Pan B 

PROVIDER: S-EPMC10331713 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature