Perioperative versus total neoadjuvant chemotherapy in gastric cancer.

ABSTRACT:

Background

Perioperative chemotherapy is standard of care management for locally advanced gastric cancer (GC), but a substantial proportion of patients do not complete adjuvant therapy due to postoperative complications and prolonged recovery. Administration of all chemotherapy prior to surgery in the form of total neoadjuvant therapy (TNT) may optimize complete delivery of systemic therapy.

Methods

We performed a retrospective review of GC patients who had surgery at Memorial Sloan Kettering Cancer Center (MSKCC) from May 2014 to June 2020.

Results

One hundred and forty-nine patients were identified; 121 patients received perioperative chemotherapy and 28 patients received TNT. TNT was chosen if patients had interim radiographic and/or clinical response to treatment.

SUBMITTER: Yang J 

PROVIDER: S-EPMC10331735 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature