Pre-operative chemoradiotherapy with or without induction chemotherapy for operable locally-advanced esophageal cancer.

ABSTRACT:

Background

For patients with operable locally advanced esophageal carcinoma (LA-EC), we hypothesized that pre-operative induction chemotherapy followed by chemoradiotherapy (IC-CRT) would improve progression-free survival (PFS) and overall survival (OS) when compared to chemoradiotherapy (CRT).

Methods

This was a single institution retrospective cohort study including patients with LA-EC who received preoperative-intent IC-CRT vs. CRT between 2013-2019. The Kaplan-Meier method was used to estimate OS and PFS. Cox proportional hazards regression was used to assess for variables associated with survival. The impact of treatment group on pathologic response was assessed by chi-square.

Results

Ninty-five patients were included for analysis (IC-CRT n=59; CRT n=36) a

SUBMITTER: Peters GW 

PROVIDER: S-EPMC10331751 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature