Comprehension of rectosigmoid junction cancer molecular features by comparison to the rectum or sigmoid colon cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a heterogeneous cancer. Its treatment depends on its anatomical site and molecular features. Carcinomas of the rectosigmoid junction are frequent; however, specific data on these tumors are sparse, as they are frequently assigned to either the colon or rectum. This study sought to identify the molecular features of rectosigmoid junction cancer to determine whether there should be any difference between the therapeutic management of rectosigmoid junction cancer and that of sigmoid colon or rectum cancer.

Methods

The data of 96 CRC patients with carcinomas in the sigmoid colon, rectosigmoid junction, and rectum were retrospectively summarized. The next-generation sequencing (NGS) data of the patients were analyzed to study the molecular ch

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10331759 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature