Prognostic evaluation of pancreatic cancer based on the model of chemo-radiotherapy resistance-related genes.

ABSTRACT:

Background

The incidence and mortality of pancreatic cancer are almost the same, and the 5-year survival rate is less than 10%. The high mortality of pancreatic cancer is related to chemo-radiotherapy. The present study aimed to establish a prognostic signature of pancreatic cancer based on chemo-radiotherapy resistant-related genes (CRRGs).

Methods

In this study, we explored the radiation-resistant and chemotherapy-resistant pancreatic cancer cell lines by colony formation and a subcutaneous tumor model in nude mice. Next, we obtained CRRGs from radiation- and gemcitabine-resistant pancreatic cancer cell lines in the Gene Expression Omnibus (GEO) database. Based on univariate Cox and least absolute shrinkage and selection operator (LASSO) Cox regression analyses, a prognost

SUBMITTER: Sun H 

PROVIDER: S-EPMC10331760 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature