Plasma Thioredoxin Reductase as a Potential Biomarker for Gynecologic Cancer.

ABSTRACT:

Background

According to previous literatures, plasma thioredoxin reductase (TrxR) level was significantly elevated in various malignant tumors and serve as a potential biomarker for diagnosis and prognostic prediction. However, there is little awareness of the clinical value of plasma TrxR in gynecologic malignancies. In the present study, we aim to evaluate the diagnostic accuracy of plasma TrxR in gynecologic cancer and explore its role in treatment surveillance.

Methods

We retrospectively enrolled 134 patients with gynecologic cancer and 79 patients with benign gynecologic disease. The difference of plasma TrxR activity and tumor markers level between two groups was compared using Mann-Whitney U test. By detecting pretreatment and post-treatment level of TrxR and conventi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10331782 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature