An integrative bioinformatics investigation and experimental validation of chromobox family in diffuse large B-cell lymphoma.

ABSTRACT:

Background

Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive malignant tumors. Chromobox (CBX) family plays the role of oncogenes in various malignancies.

Methods

The transcriptional and protein levels of CBX family were confirmed by GEPIA, Oncomine, CCLE, and HPA database. Screening of co-expressed genes and gene function enrichment analysis were performed by GeneMANIA and DAVID 6.8. The prognostic value, immune cell infiltration and drug sensitivity analysis of CBX family in DLBCL were performed by Genomicscape, TIMER2.0, and GSCALite database. Confirmatory Tests of CBX family protein expression in DLBCL were performed by immunohistochemistry.

Results

The mRNA and protein expressions of CBX1/2/3/5/6 were higher in DLBCL tissues than control groups.

SUBMITTER: Zhou F 

PROVIDER: S-EPMC10331996 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature