A robust immune-related gene pairs signature for predicting the overall survival of esophageal cancer.

ABSTRACT:

Background

Identifying reliable biomarkers could effectively predict esophagus carcinoma (EC) patients with poor prognosis. In this work, we constructed an immune-related gene pairs (IRGP) signature to evaluate the prognosis of EC.

Results

The IRGP signature was trained by the TCGA cohort and validated by three GEO datasets, respectively. Cox regression model together with LASSO was applied to construct the overall survival (OS) associated IRGP. 21 IRGPs consisting of 38 immune-related genes were included in our signature, according to which patients were stratified into high- and low-risk groups. The results of Kaplan-Meier survival analyses indicated that high-risk EC patients had worse OS than low-risk group in the training set, meta-validation set and all independent val

SUBMITTER: Zheng W 

PROVIDER: S-EPMC10332031 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature