Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years.

ABSTRACT:

Background

Physical weakness is a key component of frailty, and is highly prevalent in older adults. While females have a higher prevalence and earlier onset, sex differences in the development of frailty-related physical weakness are hardly studied. Therefore, we investigated the intramuscular changes that differentiate between fit and weak older adults for each sex separately.

Methods

Male (n = 28) and female (n = 26) older adults (75 + years) were grouped on the basis of their ranks according to three frailty-related physical performance criteria. Muscle biopsies taken from vastus lateralis muscle were used for transcriptome and histological examination. Pairwise comparisons were made between the fittest and weakest groups for each sex separately, and potential sex-specif

SUBMITTER: de Jong JCBC 

PROVIDER: S-EPMC10332038 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature