Liver in infections: a single-cell and spatial transcriptomics perspective.

ABSTRACT: The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human body. During acute and chronic infections, the liver transforms from a tolerant to an active immune state. The defence mechanism of the liver mainly depends on a complicated network of intrahepatic and translocated immune cells and non-immune cells. Therefore, a comprehensive liver cell atlas in both healthy and diseased states is needed for new therapeutic target development and disease intervention improvement. With the development of high-throughput single-cell technology, we can now decipher heterogeneity, differentiation, and intercellular communication at the single-cell level in sophisticated organs and complicated diseases. In this co

SUBMITTER: Zou J 

PROVIDER: S-EPMC10332047 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature