Chronic allergic asthma induces T-cell exhaustion and impairs virus clearance in mice.

ABSTRACT:

Background

Allergic asthma, one of the most common types of asthma, is thought to be highly susceptible to respiratory viral infections; however, its pathological mechanism needs to be elucidated. Recent studies have found impaired T-cell function in asthmatic mice. Therefore, we aimed to investigate the way by which asthma induction affects T-cell exhaustion in the lungs and assess the relationship between T-cell exhaustion and influenza viral infection.

Methods

Chronic allergic asthma mice were induced by intranasal injection of ovalbumin for 6 weeks and asthmatic features and T cell populations in lung or airway were assessed. To determine the influenza virus susceptibility, control and asthma mice were challenged with the human influenza virus strain A/Puerto Rico/8/1934

SUBMITTER: Ahn SY 

PROVIDER: S-EPMC10332059 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature