Identification of cell death-related biomarkers and immune infiltration in ischemic stroke between male and female patients.

ABSTRACT:

Background

Stroke is the second leading cause of death and the third leading cause of disability worldwide, with ischemic stroke (IS) being the most prevalent. A substantial number of irreversible brain cell death occur in the short term, leading to impairment or death in IS. Limiting the loss of brain cells is the primary therapy target and a significant clinical issue for IS therapy. Our study aims to establish the gender specificity pattern from immune cell infiltration and four kinds of cell-death perspectives to improve IS diagnosis and therapy.

Methods

Combining and standardizing two IS datasets (GSE16561 and GSE22255) from the GEO database, we used the CIBERSORT algorithm to investigate and compare the immune cell infiltration in different groups and genders. Then, fe

SUBMITTER: Chen W 

PROVIDER: S-EPMC10332266 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature