Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection.

ABSTRACT:

Introduction

Infection in diabetic foot ulcers (DFUs) is one of the major complications associated with patients with diabetes. Staphylococcus aureus is the most common offending pathogen in patients with infected DFU. Previous studies have suggested the application of species-specific antibodies against S. aureus for diagnosis and monitoring treatment response. Early and accurate identification of the main pathogen is critical for management of DFU infection. Understanding the host immune response against species-specific infection may facilitate diagnosis and may suggest potential intervention options to promote healing infected DFUs. We sought to investigate evolving host transcriptome associated with surgical treatment of S. aureus- infected DFU.

Methods

SUBMITTER: Agidigbi TS 

PROVIDER: S-EPMC10332306 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature