Long-term follow-up in common variable immunodeficiency: the pediatric-onset and adult-onset landscape.

ABSTRACT:

Introduction

The primary aim of this study is to investigate the evolution of the clinical and laboratory characteristics during the time in a longitudinal cohort of pediatric-onset and adult-onset Common Variable Immunodeficiency (CVID) patients in order to identify early predictive features of the disease and immune dysregulation complications.

Methods

This is a retrospective-prospective monocentric longitudinal study spanning from 1984 to the end of 2021. The data of pediatric-onset vs. adult-onset patients have been compared for immunological features and for infectious and non-infectious complications assessed at diagnosis and follow-up.

Results

Seventy-three CVID patients have been enrolled, with a mean of 10.0 years (SD ± 8.17) of prospective follow-up. At diag

SUBMITTER: Carrabba M 

PROVIDER: S-EPMC10332319 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature