Promoter Methylation-Regulated Differentially Expressed Genes in Breast Cancer.

ABSTRACT:

Background

Breast cancer is one of the most common malignancies among women. Recent studies revealed that differentially methylated regions (DMRs) are implicated in regulating gene expression. The goal of this research was to determine which genes and pathways are dysregulated in breast cancer when their promoters are methylated in an abnormal way, leading to differential expression. Whole-genome bisulfite sequencing was applied to analyze DMRs for eight peripheral blood samples collected from five Saudi females diagnosed with stages I and II of breast cancer aligned with three normal females. Three of those patients and three normal samples were used to determine differentially expressed genes (DEG) using Illumina platform NovaSeq PE150.

Results

Based on ontology (GO) and K

SUBMITTER: Sindi S 

PROVIDER: S-EPMC10332364 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature