Blast Crisis.

ABSTRACT:

Audience

This scenario was developed to educate emergency medicine residents on the diagnosis and management of blast crisis.

Introduction

Chronic myeloid leukemia (CML) makes up 15% of diagnosed adult leukemias with the median age of diagnosis being 67 years old. Chronic myeloid leukemia consists of three phases: chronic, accelerated, and blast phases. Most patients are initially diagnosed while in the chronic phase.1 Of those diagnosed in the chronic phase and being treated with a tyrosine kinase inhibitor (TKI), about 1% -1.5% of CML patients per year will subsequently transform into an advanced phase or blast crisis.2 While rare, blast crisis is considered an oncologic emergency, with increased mortality occurring primarily from subsequent infections or bleeding. Therefo

SUBMITTER: Kirwin M 

PROVIDER: S-EPMC10332564 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature