Comparison of Inhaled Drug Delivery in Patients With One- and Two-level Laryngotracheal Stenosis.

ABSTRACT:

Objectives/hypothesis

Laryngotracheal stenosis (LTS) is a functionally devastating condition with high respiratory morbidity and mortality. This preliminary study investigates airflow dynamics and stenotic drug delivery in patients with one- and two-level LTS.

Study design

A Computational Modeling Restropective Cohort Study.

Methods

Computed tomography scans from seven LTS patients, five with one-level (three subglottic, two tracheal), and two with two-level (glottis + trachea, glottis + subglottis) were used to reconstruct patient-specific three-dimensional upper airway models. Airflow and orally inhaled drug particle transport were simulated using computational fluid dynamics modeling. Drug particle transport was simulated for 1-20 μm particles released into the mou

SUBMITTER: Gosman RE 

PROVIDER: S-EPMC10332660 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature