CFTR regulates brown adipocyte thermogenesis via the cAMP/PKA signaling pathway.

ABSTRACT:

Background

Cystic fibrosis (CF) is characterized by reduced growth and lower body weight, which are multifactorial. CF mouse models lack key disease characteristics that predispose to a negative energy balance, such as pulmonary infections or exocrine pancreatic insufficiency, and yet they still exhibit a growth defect and an abnormally increased energy expenditure. Whether adipocyte thermogenesis contributes to the elevated resting energy expenditure in CF mice is unknown.

Methods

We examined the expression of CFTR in thermogenic brown adipose tissue (BAT) and investigated a functional role for CFTR using BAT-specific CFTR null mice (CFTR^BATKO).

Results

The CFTR protein is expressed in mouse BAT at levels comparable to those in the lungs. BAT-specific inac

SUBMITTER: Choi KM 

PROVIDER: S-EPMC10332805 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature