Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines.

ABSTRACT: Depression and obesity are both common disorders currently affecting public health, frequently occurring simultaneously within individuals, and the relationship between these disorders is bidirectional. The association between obesity and depression is highly co-morbid and tends to significantly exacerbate metabolic and related depressive symptoms. However, the neural mechanism under the mutual control of obesity and depression is largely inscrutable. This review focuses particularly on alterations in systems that may mechanistically explain the in vivo homeostatic regulation of the obesity and depression link, such as immune-inflammatory activation, gut microbiota, neuroplasticity, HPA axis dysregulation as well as neuroendocrine regulators of energy metabolism including adipocytok

SUBMITTER: Fu X 

PROVIDER: S-EPMC10333059 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature