Cross-talk of RNA modification "writers" describes tumor stemness and microenvironment and guides personalized immunotherapy for gastric cancer.

ABSTRACT:

Background

RNA modifications, TME, and cancer stemness play significant roles in tumor development and immunotherapy. The study investigated cross-talk and RNA modification roles in the TME, cancer stemness, and immunotherapy of gastric cancer (GC).

Methods

We applied an unsupervised clustering method to distinguish RNA modification patterns in GC. GSVA and ssGSEA algorithms were applied. The WM_Score model was constructed for evaluating the RNA modification-related subtypes. Also, we conducted an association analysis between the WM_Score and biological and clinical features in GC and explored the WM_Score model's predictive value in immunotherapy.

Results

We identified four RNA modification patterns with diverse survival and TME features. One pattern consistent with

SUBMITTER: Li Z 

PROVIDER: S-EPMC10333070 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature