Significance of liquid-liquid phase separation (LLPS)-related genes in breast cancer: a multi-omics analysis.

ABSTRACT: Currently, the role of liquid-liquid phase separation (LLPS) in cancer has been preliminarily explained. However, the significance of LLPS in breast cancer is unclear. In this study, single cell sequencing datasets GSE188600 and GSE198745 for breast cancer were downloaded from the GEO database. Transcriptome sequencing data for breast cancer were downloaded from UCSC database. We divided breast cancer cells into high-LLPS group and low-LLPS group by down dimension clustering analysis of single-cell sequencing data set, and obtained differentially expressed genes between the two groups. Subsequently, weighted co-expression network analysis (WGCNA) was performed on transcriptome sequencing data, and the module genes most associated with LLPS were obtained. COX regression and Lasso regression

SUBMITTER: Xie J 

PROVIDER: S-EPMC10333080 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature