Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions.

ABSTRACT: Cognitive impairment is a core clinical feature of schizophrenia, exerting profound adverse effects on social functioning and quality of life in a large proportion of patients with schizophrenia. However, the mechanisms underlying the pathogenesis of schizophrenia-related cognitive impairment are not well understood. Microglia, the primary resident macrophages in the brain, have been shown to play important roles in psychiatric disorders, including schizophrenia. Increasing evidence has revealed excessive microglial activation in cognitive deficits related to a broad range of diseases and medical conditions. Relative to that about age-related cognitive deficits, current knowledge about the roles of microglia in cognitive impairment in neuropsychiatric disorders, such as schizophrenia, is l

SUBMITTER: Zhuo C 

PROVIDER: S-EPMC10333203 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature