Macrophage-based therapy for intervertebral disc herniation: preclinical proof-of-concept.

ABSTRACT: Intervertebral disc (IVD) degeneration and herniation is a leading cause of disability globally and a large unmet clinical need. No efficient non-surgical therapy is available, and there is an urgency for minimally invasive therapies capable of restoring tissue function. IVD spontaneous hernia regression following conservative treatment is a clinically relevant phenomenon that has been linked to an inflammatory response. This study establishes the central role of macrophages in IVD spontaneous hernia regression and provides the first preclinical demonstration of a macrophage-based therapy for IVD herniation. A rat model of IVD herniation was used to test complementary experimental setups: (1) macrophage systemic depletion via intravenous administration of clodronate liposomes (Group CLP2w:

SUBMITTER: Ribeiro-Machado C 

PROVIDER: S-EPMC10333363 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature