Prenatal Exposure to General Anesthesia Drug Esketamine Impaired Neurobehavior in Offspring.

ABSTRACT: Prenatal exposure to anesthetics has raised increasing attention about the neuronal development in offspring. Animal models are usually used for investigation. As a new drug, esketamine is the s-isoform of ketamine and is twice as potent as the racemic ketamine with less reported adverse effects. Esketamine is currently being used and become more favorable in clinical anesthesia work, including surgeries during pregnancy, yet the effect on the offspring is unknown. The present study aimed to elucidate the effects of gestational administration of esketamine on neuronal development in offspring, using a rat model. Gestational day 14.5 pregnant rats received intravenous injections of esketamine. The postnatal day 0 (P0) hippocampus was digested and cultured in vitro to display the neuronal gr

SUBMITTER: Huang R 

PROVIDER: S-EPMC10333374 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature