Vasodilation promoted by (E,E)-farnesol involving ion channels in human umbilical arteries.

ABSTRACT:

Background

(E,E)-farnesol is a sesquiterpene alcohol derived from plants and animals that exhibits pharmacological properties in the cardiovascular system. However, its effects on human umbilical vessels remain unknown.

Purpose

Thus, this study aims to characterize the vasodilatory effect of (E,E)-farnesol in human umbilical arteries (HUA).

Study design

The tissue is obtained from pregnant women over 18 years of age, normotensive, and without prepartum complications. After collected, the tissue was segmented and dissected to remove Wharton's jelly and obtain the umbilical arteries segments.

Methods

HUA segments were isolated and sectioned into rings that were subjected to isometric tension recordings in an organ bath.

Results

SUBMITTER: Batista PR 

PROVIDER: S-EPMC10333471 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature