Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis.

ABSTRACT: Inference of toxicological and mechanistic properties of untested chemicals through structural or biological similarity is a commonly employed approach for initial chemical characterization and hypothesis generation. We previously developed a web-based application, Tox21Enricher-Grails, on the Grails framework that identifies enriched biological/toxicological properties of chemical sets for the purpose of inferring properties of untested chemicals within the set. It was able to detect significantly overrepresented biological (e.g., receptor binding), toxicological (e.g., carcinogenicity), and chemical (e.g., toxicologically relevant chemical substructures) annotations within sets of chemicals screened in the Tox21 platform. Here, we present an R Shiny application version of Tox21Enricher-G

SUBMITTER: Combs P 

PROVIDER: S-EPMC10333489 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature