TCA cycle metabolites associated with adverse outcomes after acute coronary syndrome: mediating effect of renal function.

ABSTRACT:

Aims

To examine relationships of tricarboxylic acid (TCA) cycle metabolites with risk of cardiovascular events and mortality after acute coronary syndrome (ACS), and evaluate the mediating role of renal function in these associations.

Methods

This is a prospective study performed among 309 ACS patients who were followed for a mean of 6.7 years. During this period 131 patients developed major adverse cardiovascular events (MACE), defined as the composite of myocardial infarction, hospitalization for heart failure, and all-cause mortality, and 90 deaths were recorded. Plasma concentrations of citrate, aconitate, isocitrate, succinate, malate, fumarate, α-ketoglutarate and d/l-2-hydroxyglutarate were quantified using LC-tandem MS. Multivariable Cox regression models were used t

SUBMITTER: Sanchez-Gimenez R 

PROVIDER: S-EPMC10333508 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature