Regulation of PD-L1 expression in non-small cell lung cancer by interleukin-1β.

ABSTRACT:

Introduction

Programmed cell death-ligand 1 (PD-L1) is a biomarker for prediction of the clinical efficacy of immune checkpoint inhibitors in various cancer types. The role of cytokines in regulation of PD-L1 expression in tumor cells has not been fully characterized, however. Here we show that interleukin-1β (IL-1β) plays a key role in regulation of PD-L1 expression in non-small cell lung cancer (NSCLC).

Methods

We performed comprehensive screening of cytokine gene expression in NSCLC tissue using available single-cell RNA-Sequence data. Then we examined the role of IL-1β in vitro to elucidate its induction of PD-L1 on NSCLC cells.

Results

The IL-1β gene is highly expressed in the tumor microenvironment, particularly in macrophages. The combination of IL-1β an

SUBMITTER: Hirayama A 

PROVIDER: S-EPMC10333574 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature