Cost-effectiveness analysis of maternal vaccination against Group B streptococcus in Japan.

ABSTRACT:

Background

Group B Streptococcus (GBS) is a leading pathogen causing life-threatening bacterial infections in neonates (early- or late-onset) and infants, and is associated with preterm and stillbirth. Japan introduced national guidelines to reduce early-onset neonatal GBS disease, with universal prenatal screening and intrapartum antimicrobial prophylaxis (IAP). However, screening/IAP does not prevent GBS associated late-onset disease, preterm or stillbirth. Maternal GBS vaccines in development are targeted at infant GBS disease but may provide benefit across perinatal outcomes. We aimed to assess cost-effectiveness of a future maternal GBS vaccine, for a base case prevention of infant GBS disease in combination with screening/IAP compared to screening/IAP alone.

Methods

We

SUBMITTER: Sorano S 

PROVIDER: S-EPMC10333677 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature