Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

A bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determine the bidirectional causal association between atopic dermatitis and CKD.

Methods

Independent genetic instruments associated with atopic dermatitis and CKD at the genome-wide significance level were chosen from corresponding meta-analyses of genome-wide association studies. Summary-level data for atopic dermatitis were obtained from the EAGLE Eczema consortium (30,047 cases and 40,835 controls) and FinnGen consortium (7,024 cases and 198,740 controls). Summary-level data for CKD were derived from CKDGen consortium (64,164 case

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10333750 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature