Using the Galleria mellonella burn wound and infection model to identify and characterize potential wound probiotics.

ABSTRACT: Burn wound infection is the leading cause of mortality among burn wound patients. One of the most commonly isolated bacterial burn wound pathogens is Pseudomonas aeruginosa, a notorious nosocomial multidrug-resistant pathogen. As a consequence of its recalcitrance to frontline antibiotic therapy, there is an urgent need to develop alternative treatment avenues to tackle this pathogen. One potential alternative infection prevention measure is to seed the wound bed with probiotic bacteria. Several species of Lactobacillus, a common commensal bacterium, have been previously reported to display growth inhibition activity against wound pathogens. Various species of this genus have also been shown to augment the wound healing process, which makes it a promising potential therapeuti

SUBMITTER: Maslova E 

PROVIDER: S-EPMC10333784 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature