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Virulence-associated type III secretion systems in Gram-negative bacteria.

ABSTRACT: Virulence-associated bacterial type III secretion systems are multiprotein molecular machines that promote the pathogenicity of bacteria towards eukaryotic host cells. These machines form needle-like structures, named injectisomes, that span both bacterial and host membranes, forming a direct conduit for the delivery of bacterial proteins into host cells. Once within the host, these bacterial effector proteins are capable of manipulating a multitude of host cell functions. In recent years, the knowledge of assembly, structure and function of these machines has grown substantially and is presented and discussed in this review.

SUBMITTER: Pais SV

PROVIDER: S-EPMC10333785 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Virulence-associated type III secretion systems in Gram-negative bacteria.

Pais Sara Vilela SV Kim Eunjin E Wagner Samuel S

Microbiology (Reading, England) 20230601 6

Virulence-associated bacterial type III secretion systems are multiprotein molecular machines that promote the pathogenicity of bacteria towards eukaryotic host cells. These machines form needle-like structures, named injectisomes, that span both bacterial and host membranes, forming a direct conduit for the delivery of bacterial proteins into host cells. Once within the host, these bacterial effector proteins are capable of manipulating a multitude of host cell functions. In recent years, the k ...[more]

PMID: 37310005

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