Transcription factor expression is the main determinant of variability in gene co-activity.

ABSTRACT: Many genes are co-expressed and form genomic domains of coordinated gene activity. However, the regulatory determinants of domain co-activity remain unclear. Here, we leverage human individual variation in gene expression to characterize the co-regulatory processes underlying domain co-activity and systematically quantify their effect sizes. We employ transcriptional decomposition to extract from RNA expression data an expression component related to co-activity revealed by genomic positioning. This strategy reveals close to 1,500 co-activity domains, covering most expressed genes, of which the large majority are invariable across individuals. Focusing specifically on domains with high variability in co-activity reveals that contained genes have a higher sharing of eQTLs, a higher variabil

SUBMITTER: van Duin L 

PROVIDER: S-EPMC10333863 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature