Proton therapy planning and image-guidance strategies within a randomized controlled trial for high-risk prostate cancer.

ABSTRACT: The Danish Prostate Cancer Group is launching the randomized trial, PROstate PROTON Trial 1 (NCT05350475), that compares photons and protons to the prostate and pelvic lymph nodes in treatment of high-risk prostate cancer. The aim of the work described in this paper was, in preparation of this trial, to establish a strategy for conventionally fractionated proton therapy of prostate and elective pelvic lymph nodes that is feasible and robust. Proton treatments are image-guided based on gold fiducial markers and on-board imaging systems in line with current practice. Our established proton beam configuration consists of four coplanar fields; two posterior oblique fields and two lateral oblique fields, chosen to minimize range uncertainties associated with penetrating a varying amount of mate

SUBMITTER: Tilbæk S 

PROVIDER: S-EPMC10334116 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature