The contribution of competing mechanisms in stroke despite anticoagulation in patients with atrial fibrillation.

ABSTRACT:

Background

For reasons poorly understood, strokes frequently occur in patients with atrial fibrillation (AF) despite oral anticoagulation. Better data are needed to inform randomised trials (RCTs) of new strategies to prevent recurrence in these patients. We investigate the relative contribution of competing stroke mechanisms in patients with AF who have stroke despite anticoagulation (OAC+) compared with those who are anticoagulant naïve (OAC-) at the time of their event.

Patients and methods

We performed a cross-sectional study leveraging data from a prospective stroke registry (2015-2022). Eligible patients had ischemic stroke and AF. Stroke classification was performed by a single stroke-specialist blinded to OAC status using TOAST criteria. The presence of atherosclerot

SUBMITTER: Herlekar R 

PROVIDER: S-EPMC10334183 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature