Genetic liability to migraine and functional outcome after ischemic stroke.

ABSTRACT:

Background and purpose

To evaluate the association of genetic liability to migraine with functional outcome after ischemic stroke using Mendelian randomization.

Methods

Genetic proxies for migraine were obtained from the largest genome-wide association study meta-analysis of 102,084 migraine cases and 771,257 controls. Genetic associations with functional outcome after ischemic stroke were obtained from the Genetics of Ischemic Stroke Functional Outcome network study (N = 6021). Poor functional outcome after ischemic stroke was defined as a score of 3-6 on the modified Rankin scale at 3 months (N = 2280). The inverse-variance weighted method was used to estimate the association of genetic liability to migraine with functional outcome, and we performed sensitivi

SUBMITTER: Wang M 

PROVIDER: S-EPMC10334186 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature