Effectiveness of Bundled Hyperpolypharmacy Deprescribing Compared With Usual Care Among Older Adults: A Randomized Clinical Trial.

ABSTRACT:

Importance

Older patients using many prescription drugs (hyperpolypharmacy) may be at increased risk of adverse drug effects.

Objective

To test the effectiveness and safety of a quality intervention intended to reduce hyperpolypharmacy.

Design, setting, and participants

This randomized clinical trial allocated patients 76 years or older who used 10 or more prescription medications to a deprescribing intervention or to usual care (1:1 ratio) at an integrated health system with multiple preexisting deprescribing workflows. Data were collected from October 15, 2020, to July 29, 2022.

Intervention

Physician-pharmacist collaborative drug therapy management, standard-of-care practice recommendations, shared decision-making, and deprescribing protocols administered by

SUBMITTER: Herrinton LJ 

PROVIDER: S-EPMC10334220 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature