Colony-stimulating factor 1 positive (CSF1⁺ ) secretory epithelial cells induce excessive trophoblast invasion in tubal pregnancy rupture.

ABSTRACT: Tubal ectopic pregnancy (TEP) occurs when an embryo aberrantly implants in the fallopian tube, leading to abortive or ruptured tubal ectopic pregnancy (AEP or REP). Poor outcomes of REP include maternal infertility or mortality. Current studies on the prevention and treatment of ruptured tubal ectopic pregnancy (REP) are unfortunately hampered by a lack of the cell spectrum and cell-cell communications in the maternal-foetal interface. Here, we investigate the mechanisms of tubal rupture through single-cell transcriptome profiling of the fallopian tube-trophoblast interface in REP, AEP and intrauterine pregnancy patients. In REP, extravillous trophoblast (EVTs) cells form a dominant cell population, displaying aggressive invasion and proliferation, with robust differentiation into three su

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10334268 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature