RB1 aberrations predict outcomes of immune checkpoint inhibitor combination therapy in NSCLC.

ABSTRACT:

Introduction

Immune checkpoint inhibitors (ICI) have changed the treatment of non-small cell lung cancer (NSCLC). Furthermore, compared with monotherapy, ICI combination therapy had better efficacy and partly different mechanism. Therefore, we aim to investigate and improve biomarkers specialized for ICI combination therapy.

Methods

We enrolled 53 NSCLC patients treated with ICI combination therapy and collected their tissue and plasma samples to perform next-generation sequencing (NGS) with a 425-gene panel.

Results

The line of treatment was the only clinical factor significantly affecting objective response rate (ORR) and progression-free survival (PFS). Surprisingly, classical markers PD-L1 and TMB only had limited predictive values in the ICI combination therapy.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10334286 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature