Postsynaptic density radiation signature following space irradiation.

ABSTRACT: Introduction: The response of the brain to space radiation is an important concern for astronauts during space missions. Therefore, we assessed the response of the brain to ²⁸Si ion irradiation (600 MeV/n), a heavy ion present in the space environment, on cognitive performance and whether the response is associated with altered DNA methylation in the hippocampus, a brain area important for cognitive performance. Methods: We determined the effects of ²⁸Si ion irradiation on object recognition, 6-month-old mice irradiated with ²⁸Si ions (600 MeV/n, 0.3, 0.6, and 0.9 Gy) and cognitively tested two weeks later. In addition, we determined if those effects were associated with alterations in hippocampal networks and/or hippocampal DNA methylation. <

SUBMITTER: Impey S 

PROVIDER: S-EPMC10334289 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature